Electrically induced C-H bond functionalization
Wang, Zhiqing (2018)
Wang, Zhiqing
Tampereen ammattikorkeakoulu
2018
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Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:amk-201901231505
https://urn.fi/URN:NBN:fi:amk-201901231505
Tiivistelmä
In recent years, with the deepening of environmental awareness and the development of technology, organic electrochemical synthesis are becoming more and more popular in the society, organic electrochemical synthesis is the combination of electrochemical and and organic synthesis, with the help of the technology of electrochemical, the transformation ,the catalytic efficiency have been increased greatly. Using catalytic as a catalyst, organic electrochemical synthesis saves natural resources reduce the use of precious metal catalyst and improved the reaction efficiency compared to organic synthesis. organic electrochemical synthesis have many advantages. For example, the reaction is easily to control and it costs less than organic synthesis and so on.
This paper mainly discusses the effects of electrolytes, bases, solvent reaction time, temperature, etc. on the reaction, the progress of C-H bond functionalization at home and abroad, and focuses on the author's own experiments and related progress.
In this paper, N,N-dimethyl benzene was used as the reactant and acetonitrile (CH3CN) as the solvent. Anhydrous sodium carbonate and lithium perchlorate were added. The reaction was carried out on an intelligent magnetic stirrer to obtain a small molecule compound. . In order to obtain better experimental results, the reaction was optimized several times, and the appropriate electrolyte, alkali, time, and temperature were determined. The product was then processed in a step-by-step manner. After detection by GC-MS instrument, the possible structure of the product was obtained, and several possible products and simulated products were ionized in the mass spectrometer by further analysis of the spectrum. Mass-to-charge ratio. 摘 要
近年来,随着绿色环保意识的深入人心和科技的发展,有机电化学越来越受到人们的推崇,有机电化学合成是电化学与有机合成的结合,具有反应以控制、成本低等诸多优点.有机电化学是对环境友好的绿色化学,反应符合高效,原子经济性等现在合成理念。
本论文主要讲了电解质,碱,溶剂反应时间,温度等对反应的影响,C-H键官能团化国内外取得的一些进展,并着重讲述了作者本人所做的实验及相关进展。
本实验是关于如何在电化学条件下制备N,N,N',N'-四甲基联苯胺。近年来,由于其在各种领域的适用性,制备结构多样的联苯胺衍生物的高效合成方法的开发近年来受到越来越多的关注。联苯胺基化合物的化学和物理性质使其能够用于制造偶氮化合物和 在细胞生物学中作为染色试剂。本论文的实验以N,N-二甲基苯烷为反应物,以乙腈(CH3CN)为溶剂,加入无水碳酸钠和高氯酸锂,在智能磁力搅拌器上进行反应,得到小分子化合物。之后为了得到更好的的实验产率对反应进行了数次条件优化,确定了合适的电解质,碱,时间及温度。然后通过一步步处理得到纯产物,通过MS图和核磁共振氢谱图进一步确定了产物确实是N,N,N',N'-四甲基联苯胺。
This paper mainly discusses the effects of electrolytes, bases, solvent reaction time, temperature, etc. on the reaction, the progress of C-H bond functionalization at home and abroad, and focuses on the author's own experiments and related progress.
In this paper, N,N-dimethyl benzene was used as the reactant and acetonitrile (CH3CN) as the solvent. Anhydrous sodium carbonate and lithium perchlorate were added. The reaction was carried out on an intelligent magnetic stirrer to obtain a small molecule compound. . In order to obtain better experimental results, the reaction was optimized several times, and the appropriate electrolyte, alkali, time, and temperature were determined. The product was then processed in a step-by-step manner. After detection by GC-MS instrument, the possible structure of the product was obtained, and several possible products and simulated products were ionized in the mass spectrometer by further analysis of the spectrum. Mass-to-charge ratio.
近年来,随着绿色环保意识的深入人心和科技的发展,有机电化学越来越受到人们的推崇,有机电化学合成是电化学与有机合成的结合,具有反应以控制、成本低等诸多优点.有机电化学是对环境友好的绿色化学,反应符合高效,原子经济性等现在合成理念。
本论文主要讲了电解质,碱,溶剂反应时间,温度等对反应的影响,C-H键官能团化国内外取得的一些进展,并着重讲述了作者本人所做的实验及相关进展。
本实验是关于如何在电化学条件下制备N,N,N',N'-四甲基联苯胺。近年来,由于其在各种领域的适用性,制备结构多样的联苯胺衍生物的高效合成方法的开发近年来受到越来越多的关注。联苯胺基化合物的化学和物理性质使其能够用于制造偶氮化合物和 在细胞生物学中作为染色试剂。本论文的实验以N,N-二甲基苯烷为反应物,以乙腈(CH3CN)为溶剂,加入无水碳酸钠和高氯酸锂,在智能磁力搅拌器上进行反应,得到小分子化合物。之后为了得到更好的的实验产率对反应进行了数次条件优化,确定了合适的电解质,碱,时间及温度。然后通过一步步处理得到纯产物,通过MS图和核磁共振氢谱图进一步确定了产物确实是N,N,N',N'-四甲基联苯胺。